Current studies show that fat tissue is an active secretion organ. We call the proteins released from fat tissue that carry signals from cell to cell adipokines. While adipokines regulate appetite and energy consumption centrally, they have been shown to have an effect on insulin sensitivity and change oxidative capacity in the periphery. With the discovery of leptin, the process of accepting adipose tissue as an endocrine organ began and in the following years, many adipokines released from adipose tissue were discovered. There are biologically active molecules in adipose tissue that are secreted not only from adipocytes but also from adipose tissue macrophages, and these are included in adipokines. Obesity and increased fat tissue are associated with many diseases, especially insulin resistance. Understanding this relationship will only be possible by understanding the messengers, namely adipokines, that are released from fat tissue and affect other organs. A better understanding of adipokines may enable understanding of the mechanisms that lead to diabetes and other metabolic diseases and the development of new treatment strategies. Adipokines secreted from adipose tissue can be listed as cytokines, chemokines, acute phase proteins and proinflammatory biomolecules. The effects of adipokines are better understood day by day through studies. Adiponectin, an adipokine whose effects are well understood, shows anti-inflammatory and anti-atherogenic properties. Its level appears to be low in obesity and type 2 diabetes. Leptin is synthesized from many tissues, especially subcutaneous fat tissue. It has been observed that it has a function of keeping the amount of body fat tissue constant, with its effects on appetite and fat burning. Tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), secreted from macrophages in adipose tissue, are also considered adipokines and have a central role in inflammatory cell activation. It has been shown to cause insulin resistance in skeletal muscle and adipose tissue. Adipokines are basically; In addition to its negative effects such as being involved in the chronic inflammation process, creating insulin resistance and atherogenic effects, there are also adipokines that increase insulin sensitivity and have anti-atherogenic effects. It is important to fully understand the complex pathways of action of adipokines in the body in order to understand and develop ways to correct the metabolic functioning that is disrupted in the body due to the increase in fat tissue.